When looking at the Ozone and Medical Ozone industry in the 21st century it is not surprising that the most significant problem is the lack of one central global organization. Ozone for medicinal use is a brilliant, safe and reliable treatment with the potential ability to save untold billions of morbidity. The medical doctors and ozone physicians have a duty and a responsibility to advocate on behalf of these therapies. However, in spite of all of the evidence attesting to the safety and reliability of Ozone for medicinal use, it is still being questioned and challenged in the minds of many governments and medical organizations. So, the magic question is how can the world of medical ozone become an accepted and widely used treatment in the United States and abroad?